In order to investigate the immunomodulational effects of ATE(A. triphylla var. japonica HAM. extract). The author measured proliferation of lymphocytes, increase and decrease of CD4 , CD8 T cells, CD19 B cells, gene expression of the IL-10, IL-l2(P35), IL12(P40), IFN- y , and creation of IgE.
The results were obtained as follows:
1. The number of lymphocytes was significantly increased at the all degree of density compared with control group.
2. ATE reduced the number of CD4 T cell, CD8 T cell and enhanced the number of CD19 B cells, macrophage. (ill vivo and in vitro)
3. ATE significantly enhanced the gene expression of IL-I2(P35), IL-l2(P40), IL-I0 and somewhat reduced the gene expression of IFN- y.
4. Compared with the control group, the creation of IgE was dereased.
The above results demonstrate that A. triphylla var. japonica HARA. can be used more effectively in the disease such as allergy and other diseases concerned with IL-12, IL-10 by enhancing the gene expression of IL-12, IL-I0 and by prohibiting the creation of IgE.
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